an artefact is that which is produced by someone, it usually has memetic fingerprints left over from the culture of whence it came.
"I think the information-theory definitions are essentially undesirable. They don't include the whole of culture. Culture is not just memes, it is also meme products. The meme products are important mediators of cultural influences - and seem more like part of the whole phenomenon than something separate from it." - Tim tyler 
Art is art. It is an artefact.
That artefact can be abstracted into another meme.
how memes spread. It's how multiple can have the same idea spontaneously. Via abstraction
Meme can be in a corporeal artefact. But it gets abstracted within norms.- reproduces